From the panel of four EV miRNA biomarkers, miR-598-3p in CD24+ EVs and miR-15b-5p in HER2+ EVs were differentially enriched between women with high-risk benign lesions compared to women with low-risk benign lesions, and the panel achieved an AUC of 0.93 for classifying women with low-risk benign lesions compared to high-risk benign and malignant lesions. This evidence concerns the gene ERBB2 and cancer.