Fra1, encoded by FOSL1, is known to operate as a heterodimeric complex with other members of the activator protein- 1 (AP- 1) complex, such as FosB. High expression of Fra1 is closely associated with tumor cell proliferation, apoptosis, and migratory events, exerting oncogenic effects, and is correlated with advanced tumor stage and poor survival in non-small cell lung cancer patients [36]. This evidence concerns the gene FOSB and non-small cell lung carcinoma.