After adjusting for age, gender, years of education, disease duration, seizure type, hypertension, diabetes, and dyslipidemia, high seizure frequency (OR = 3.94, 95% CI [1.34, 11.61], P = 0.013) and the number of APOE ε4 alleles (OR = 3.28, 95% CI [1.09, 9.83], P = 0.034) were found to be associated with CI, respectively. This evidence concerns the gene APOE and diabetes mellitus.