As the most enhancers preferentially activate their neighbor genes, we analyzed the genes surrounding these active enhancers (± 500 kb) by HBV-SITE-1, which were expectedly enriched in the terms including cell cycle, metabolic process, as well as interleukin-7-mediated signaling pathway with more than 1600 literature related to cancer (Fig. 2F). This evidence concerns the gene IL7 and cancer.