CDK8 and neoplasm: As cell cycle gene CDK8, usually involved in tumor growth, was one of the most potential targets activated by HBV-SITE-1, we performed ChIP-seq and displayed that the H3K27ac peaks were located at about 30 kb upstream of CDK8 promoter (Fig. 2H), which was verified as active enhancer by ChIP-qPCR (Fig. 2G).