COL1A1 and hepatocellular carcinoma: Importantly, these 369 genes were enriched in angiogenesis (CD34), cell cycle (CCNA2, CCND1), cell adhesion and migration, inflammatory response, collagen fiber and ECM organization (COL1A1 and LOXL2) (Fig. 5C), which were crucial for the malignant progression of HCC [76–78].