Meanwhile, HBV infection directly caused the significant upregulation of the collagen fibril genes (COL12A1, COL1A1, COL3A1, COL1A2, COL5A1, and COL5A3) and extracellular matrix organization genes (COL15A1, COL4A2, COL4A1, and COL8A1), and clearly, HBV-miR-2 inhibitor could block the upregulation of these genes (Fig. S7F), highlighting that HBV-SITE-1 resulting in the liver fibrosis by affecting ECM gene upregulation could be reversed by HBV-miR-2 inhibitor. The gene discussed is COL5A3; the disease is Hepatic fibrosis.