CD8A and rheumatic disorder: To figure out if the differing proportions of inflammatory CD8 TEMRA cells between the csDMARD-only and the TNFi treated patients are due to the medication, or whether they are features of the underlying rheumatic disease requiring the particular treatment forms, linear regression analyses of the proportions of IFNγ+CD8+TEMRA cells against the treatment duration were performed (Fig. 5B).