Performing multiple linear regression analyses to dissect the influence of the RA and its treatment options on the inflammatory cytokine secreting T cells, the regression models revealed a negative association between the RA disease occurrence (or the DMARD-treatment in its entirety as no untreated patients were included) and a positive association of TNFi treatment with the proportions of inflammatory T cells, such as IFNγ+CD8+ T cells and Th17 cells. The gene discussed is CD8A; the disease is rheumatoid arthritis.