SPDL1 and juvenile polyposis syndrome: Compared to controls, sPD-L1 levels in plasma were significantly higher in PJI patients at explantation (0.003 vs 0.014 ng/mL, p = 0.001) and were reduced compared to at explantation but elevated compared to the control at reimplantation (0.003 vs 0.006, p = 0.325; Fig. 3A).