Additionally, after treatment with PD-L1, both osteoclast number and surface were significantly higher in PJI (osteoclasts: 13.263 vs 9.284 cells/mm2, p = 0.021; osteoclast surface: 17.9% vs 28.2%, p < 0.001, Fig. 4B-E). The gene discussed is CD274; the disease is juvenile polyposis syndrome.