Mirian et al. [55] studied TLR-4 and the linker molecule Serile Aha and TIR Motif-containing 1 (SARM1) in HPV-positive cervical cancer cell line HeLa cells and found that knocking out TLR-4 or SARM1 could reduce HeLa cell proliferation and viability and proved that TLR-4-knockout cells were more sensitive to cisplatin by promoting tumor cell apoptosis. This evidence concerns the gene SARM1 and neoplasm.