Zhang et al. [41] found in vitro that Fusobacterium nucleatum (Fn) could up-regulate the expression of baculoviral IAP repeat-containing 3 (BIRC3) through the TLR-4/NF-κB pathway, ultimately reducing CRC cell chemosensitivity to 5-FU. The gene discussed is BIRC3; the disease is colorectal carcinoma.