Among them, 17 genes (APC, ATM, BRAF, BRCA1, BRCA2, CDKN2A, CTNNB1, KRAS, MET, MLH1, MSH2, MSH6, PIK3CA, PKHD1, PMS2, RET, TP53) showed a significant difference in expression between tumor and normal tissues (Fig. 6A). This evidence concerns the gene PIK3CA and neoplasm.