Moreover, as discussed earlier, the absence of notable differences in BMDM reprogramming effects between SB28-TSP1-WT and KO cells in vitro (Supplementary Fig. 19) led us to hypothesize that excitatory neuronal synaptic activity may drive immunosuppression in the context of hyperexcitable glioblastoma. Here, THBS1 is linked to glioblastoma.