TNF and neoplasm: Within the estimated tumor infiltration areas with mixed CNA indices, we recurrently observed inverse correlations, to varying extents, between neuro-synaptic gene signature scores (represented by the gene set Postsynaptic Neurotransmitter Receptor Activity [GO:MF]) and pro-inflammatory signature scores (represented by the gene sets TNFα-via-NFκB Signaling Pathway, IFNγ Response, and Inflammatory Response [all from Hallmark]) (Fig. 2c and Supplementary Fig. 6).