RB1 and small cell lung carcinoma: Given the established role of RB1 in SCLC biology, we conducted survival analysis based on the mutation status of RB1. ES-SCLC with wild type RB1 showed superior PFS but discrepancy in OS was not significant (PFS: HR = 0.35, 95%CI: 0.13–0.96; OS: HR = 0.48, 95%CI: 0.16–1.47; Supplementary Fig. 2b-c).