B cell markers (MS4A1, CD19, IGLL5, and CD200), together with markers of follicular T cells (IRF4 and CXCR5) and tissue-resident memory T cells (ITGAE, also named CD103), were highly expressed in the DCB group, while markers of immune suppressive tumor-associated macrophages (TAM) (CSF1R, SIGLEC5 and CD68) were enriched in the NDB group (Fig. 3a). The gene discussed is IRF4; the disease is neoplasm.