They are implicated in diverse homeostatic regulation and pathogenesis underlying cancer, chronic neurological diseases, diabetes, and cardiovascular disorders.59 It has been reported that FoxO knockout in mice contributed to increased oxidative stress and accelerated atherosclerosis.60 Our proteomic analysis revealed that only FOXO3 was differentially expressed in Pg-exposed macrophages. The gene discussed is JUP; the disease is cardiovascular disorder.