GZMB and central nervous system cancer: Overall, treated patient explants revealed a profound reversal of local immunosuppression putatively driven by M2-like glioma-associated microglia and myeloid infiltrates, as suggested by Arginase 162 and regulatory T cells fostered by ICOSL63 to an inflammatory hotspot, characterized by cytotoxic mediators including FASLG, GZMB, GZMH, chemokines CXCL9, CXCL10 and CXCL1164,65 and the T effector cell activating TNF receptor family member OX4066.