IL1B and coronary artery disorder: Targeting glycolysis, superoxide, and PKM2 tetramerization could potentially correct this pro-inflammatory phenotype.607 Macrophages from CAD patients are prolific producers of T cell chemo attractants (CXCL9, CXCL10), pro-inflammatory cytokines (IL-1β, IL-6), and the immunosuppressive ligand PD-L1, highlighting their significant role in exacerbating the inflammatory environment.608 NPM1 recruits histone demethylase KDM5b to the Tsc1 promoter, erasing H3K4me3 marks, inhibiting TSC1 expression, and enhancing mTOR signaling.