By sponging miR-122, circRNA_002581 promotes a pro-inflammatory macrophage phenotype, which contributes to vascular inflammation and cardiac hypertrophy.559 circRNA_010567 promotes the activation of the NF-κB pathway by sponging miR-141, which targets a key inhibitor of NF-κB. The gene discussed is NFKB1; the disease is cardiac hypertrophy.