In M2 macrophage-derived small extracellular vesicles (SEVs), circUbe3a promotes myocardial fibrosis by targeting the microRNA-138-5p/RhoC axis, driving cardiac fibroblast proliferation, migration, and phenotypic transformation, thereby worsening myocardial fibrosis after MI560 (Fig. 7c). This evidence concerns the gene RHOC and Myocardial fibrosis.