Dotan et al. demonstrated that Apoe−/− mice deficient in macrophage Jak2 developed accelerated atherosclerosis.526 Additionally, An et al. found that STAT3/NF-∣B decoy oligodeoxynucleotides (ODNs) reduced atherosclerosis by modulating the STAT/NF-∣B signaling pathway in mice.527. This evidence concerns the gene APOE and atherosclerosis.