This indicates that β-catenin contributes to post-MI inflammation by activating the NF-κB pathway.507 Dysregulated Wnt/β-catenin activation has also been observed in the pathogenesis of pressure overload-induced cardiac hypertrophy cardiac hypertrophy in mice, while interruption of Wnt signaling was found to attenuatecardiac dysfunction.508. This evidence concerns the gene NFKB1 and cardiac hypertrophy.