CD4 and atherosclerosis: MYDGF levels rise in the left ventricular myocardium and blood plasma of pressure-overloaded mice, which enhances sarcoplasmic/endoplasmic reticulum Ca2+-ATPase 2a (SERCA2a) expression, reduces hypertrophy and dysfunction, and improves survival rates in both mice and patients with severe aortic stenosis.593 Furthermore, EGFR blockade in CD4 + T cells induces T cell anergy and reduces the development of atherosclerosis.