IRF5 and atherosclerosis: CD47-blocking antibodies reverse this defect, normalize the clearance of diseased vascular tissue, and ameliorate atherosclerosis.612 Efferocytosis-derived nucleotides activate a DNA-PKcs-mTORC2/Rictor pathway, promoting non-inflammatory macrophage proliferation, apoptotic cell clearance, and tissue resolution, aiding in atherosclerosis regression and plaque stabilization.613 Myeloid CD147 promotes atherosclerosis by enhancing inflammation via the TRAF6-IKK-IRF5 pathway and inhibiting efferocytosis by suppressing GAS6.