IGF1R-deficient macrophages showed enhanced pro-inflammatory responses and reduced lipid efflux, increasing atherosclerosis and plaque instability.597 Eosinophils and eosinophil cationic protein (ECP) promote SMC calcification and atherogenesis via the BMPR-1A/1B-Smad-1/5/8-Runx2 signaling pathway. The gene discussed is RNASE3; the disease is atherosclerosis.