DDX41 and coronary artery disorder: While current studies have not widely investigated the direct role of DDX41 in CVDs, there is emerging evidence suggesting its potential significance.379 Mutations in DDX41 have been associated with CVDs.380 The DDX41/cGAS/STING-mediated interferon inflammation has been linked to an increased risk of adverse outcomes in coronary artery disease due to the deletion of myocyte enhancing factor 2 (MEF2).381 These findings suggest that DDX41 may play a role in the regulation of cardiovascular conditions, highlighting the urgent need for further research into its clinical applications.