Targeting glycolysis, superoxide, and PKM2 tetramerization could potentially correct this pro-inflammatory phenotype.607 Macrophages from CAD patients are prolific producers of T cell chemo attractants (CXCL9, CXCL10), pro-inflammatory cytokines (IL-1β, IL-6), and the immunosuppressive ligand PD-L1, highlighting their significant role in exacerbating the inflammatory environment.608 NPM1 recruits histone demethylase KDM5b to the Tsc1 promoter, erasing H3K4me3 marks, inhibiting TSC1 expression, and enhancing mTOR signaling. This evidence concerns the gene TSC1 and coronary artery disorder.