All JNK isoforms play a specific role in various diseases.Therole of the JNK2 isoform has so far received little attention comparedto its JNK1 and JNK3 counterparts with JNK3 being a potential targetfor neurodegenerative diseases and an inhibitor with JNK1 bias beingcurrently investigated in clinical trials. Here, MAPK8 is linked to neurodegenerative disease.