Among them, ATAD2 (ATPase family AAA domain-containing protein 2) is known to mediate the loading and removal of histone H3-H4 and is frequently overexpressed in various cancers, where it is associated with poor prognosis (Caron et al., 2 010, Kalashnikova et al., 2010, Zou et al., 2007). Here, ATAD2 is linked to cancer.