In addition, the AD/ADA-driven transientframeworks are integrated into liposome assemblies as protocell models.Functionalized liposomes carrying allosterically ATP-stabilized DNAzymescleaving EGR-1 mRNA are fused with MCF-7 breast cancer cells, demonstratingeffective gene therapy and selective apoptosis of cancer cells. The gene discussed is EGR1; the disease is breast cancer.