POSTN and myocardial ischemia: Although the link between myocardial inflammation and liver dysfunction remains unclear, a recent study demonstrated that myocardial ischemia and AMI in particular exacerbates liver damage in MAFLD through two mechanisms: (1) increasing inflammatory monocyte levels and their recruitment to the liver, and (2) secreting periostin (POSTN), an extracellular matrix protein re-expressed by cardiac fibroblasts during cardiac injury286.