A meta-analysis of studies evaluating pancreatic size and fat content through ultrasound, CT, and MRI concluded that excess pancreatic fat seen in diabetes leads to β-cell reduction and impaired insulin secretion, contributing to hyperglycemia and metabolic dysregulation.148 Individuals with diabetes and obesity often exhibit increased pancreatic fat, which correlates with factors such as waist circumference, triglyceride levels, hyperferritinemia, visceral adipose tissue, and insulin resistance.149,150. This evidence concerns the gene INS and diabetes mellitus.