Patients with advanced stages of CKD have a permanent status of fluid overload, resulting in hypertension in 60% to 90% of the patients depending on the CKD stage.82,83 This is caused by the continuous activation of the RAAS, the sympathetic nervous system (SNS), and mineralocorticoid receptor (MR) signaling. The gene discussed is NR3C2; the disease is hypertensive disorder.