A disturbed Ca2+ homeostasis in cardiomyocytes of CKD mice could also be improved by blocking the proinflammatory innate immune receptor NOD1 (nucleotide-binding oligomerization domain-containing protein 1) or its downstream kinase RIP2 (receptor-interacting serine/threonine protein kinase 2).154. The gene discussed is NOD1; the disease is chronic kidney disease.