In short, a more consistent induction of uremic cardiomyopathy with signatures of cardiac hypertrophy, fibrosis, and dysfunction has been observed in 129/Sv mice compared with C57BL/6 mice.31,108 Compared with C57BL/6 mice, 129/Sv mice express 2 instead of 1 renin gene and more consistently develop increased blood pressure upon CKD induction. This evidence concerns the gene REN and chronic kidney disease.