To investigate potential mechanisms underlying the increased susceptibility to HFCC diet-induced coronary artery atherosclerosis observed in 52 w.o. SR-B1KO/KO mice, we examined levels VCAM-1 in non-atherosclerotic coronary arteries, since induction of VCAM-1 protein the intima of arteries plays a major role in the initiation of atherosclerosis [3–6]. The gene discussed is VCAM1; the disease is atherosclerosis.