On the other hand, genetic KO of expression or function of scavenger receptor class B type I (SR-B1) in ApoEKO/KO or LdlrKO/KO mice not only accelerates spontaneous and high-fat/high-cholesterol diet-induced atherosclerosis development in the aortic sinus, but triggers the development of occlusive coronary artery atherosclerosis accompanied by fatal myocardial infarction [15–22]. This evidence concerns the gene SCARB1 and atherosclerosis.