Therefore, female SR-B1KO/KO mice, in which atherosclerosis development appears to be entirely dependent on atherogenic diet feeding, may prove to be a useful mouse model to dissect the pathways that are involved in age-dependent CAD development, particularly in the context of preserved LDL and VLDL clearance pathways (due to intact Ldlr and ApoE expression). The gene discussed is APOE; the disease is atherosclerosis.