Therefore, female SR-B1KO/KO mice, in which atherosclerosis development appears to be entirely dependent on atherogenic diet feeding, may prove to be a useful mouse model to dissect the pathways that are involved in age-dependent CAD development, particularly in the context of preserved LDL and VLDL clearance pathways (due to intact Ldlr and ApoE expression). This evidence concerns the gene APOE and coronary artery disorder.