Of all three human desaturases, FADS2 and SCD1 are most frequently dysregulated in cancer, with FADS2 overexpression being associated with increased disease progression in uveal melanoma, bladder urothelial carcinoma, clear cell renal carcinoma, and lung and pancreatic adenocarcinomas [29]. Here, FADS2 is linked to pancreatic adenocarcinoma.