Rheumatoid arthritis (RA) is an autoimmune disability associated with inflammation of synovium, hyperplasia, production of autoantibodies like rheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA), cartilage and bone deformity, and systemic manifestations such as cardiovascular, pulmonary, psychological and skeletal disorders. The gene discussed is PRTN3; the disease is rheumatoid arthritis.