Interestingly, there was a decrease in number of protective CD11b+Ly6ChiLy6G– cells in mSTING mice in severe PH, consistent with our previously published findings across a variety of preclinical models (21, 33) and peripheral blood samples from patients with PAH (34) (Figure 5B and Supplemental Figure 8B). This evidence concerns the gene ITGAM and pulmonary arterial hypertension.