KRAS and colorectal carcinoma: Similarly, the panel variants of 4-biomarker stool test Cologuard (KRAS, mBMP3, mNDRG4, FIT) managed to achieve performances above 90% for overall CRC sensitivity and specificity, with suboptimal performances for APL detection, compared to other options, with the highest detection rate of 57% (65/114) by Lidgard et al. [57].