Ciaroloni et al. used a panel with 29 genes, CEA and CYFRA21-1 and Li et al. an 80-marker panel including methylated SEPT9 and IKZF1, achieving a similar performance for CRC detection with sensitivities of 78.1% and 77.0%, and specificities of 92.2% and 90.0%, respectively. Here, SEPTIN9 is linked to colorectal carcinoma.