TFPI2 and colorectal carcinoma: Another example of a high-performance panel is, ColoCaller, a recently reported stool-based 4-biomarker panel of methylated NDRG4, SDC2, TFPI2, and WIF1, exhibiting excellent performance for overall CRC (94.9% sensitivity, 37/39 and 98.1% specificity, 105/107) and APL detection (100% sensitivity, 6/6) [62].