5 Intra-abdominal necrotizing fasciitis should be part of a broad differential considered in the ED to reduce the mortality and morbidity associated with this condition. One tool is the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score to distinguish necrotizing fasciitis from severe cellulitis or abscess, which takes into account C-reactive protein, WBC, hemoglobin, sodium, creatinine, and glucose.6 This evidence concerns the gene CRP and fasciitis.