Additionally, we observed ectodermal EtOH-induced alterations in several genes, such as LHX2, SHANK2, TRIO, ZMYND8, ARX, NRXN3 and SEMA5A, that have also been associated with autism spectrum disorder (ASD) (SFARI Gene Database, 2024; accessed: 1, August, 2024). The gene discussed is SHANK2; the disease is autism spectrum disorder.