In line, PAH is also associated with increased metabolic rates and elevated glycolysis, measured as increased levels of glycolytic and glutaminolysis-related enzymes, such as glucose transporter 1 (GLUT1), hexokinase 2 (HK2), lactate dehydrogenase A (LDHA), glutamate dehydrogenase 1 (GLUD1), and pyruvate dehydrogenase kinase (PDK) (14). Here, HK2 is linked to pulmonary arterial hypertension.