The accumulation of the autophagy-lysosomal pathway components in a cell is observed in many neurodevelopmental diseases [48]; for example, variants in CLN3 cause neuronal ceroid lipofuscinosis and a specific accumulation of lysosomes in the perinuclear region have also been detected in CLN3 deficits [49]. The gene discussed is CLN3; the disease is infantile neuronal ceroid lipofuscinosis.