CNR1 and depressive symptom measurement: The 5-HT2A and 5-HT2C receptors within the serotonergic system influence mood regulation and impulse control which explains their significance in addiction treatment.33 Selective serotonin reuptake inhibitors (SSRIs) have been investigated for treating patients with both depression and addiction but show limited effectiveness as direct treatments for substance use disorders.34 The cannabinoid receptor 1 (CB1) has gained research interest as a therapeutic target because of its significant influence on reward and stress-related responses.