F8 and type 2 diabetes mellitus: The presence of both CAD and T2DM can activate intrinsic- and extrinsic-coagulation pathways, elevate factor VIII (FVIII) levels, shorten activated partial thromboplastin time (APTT), and reduce the activity of anticoagulant proteins [protein C, protein S, and antithrombin (AT)], leading to a sustained hypercoagulable state and a high risk for thrombosis (2–4).