FGFR2 and cholangiocarcinoma: 9,10 In addition, chronic infection with hepatitis B and C viruses (hepatitis B virus and hepatitis C virus) may also be associated with CC.11,12 In our patient, 2 pathogenic single nucleotide variants in the FGFR2 gene and a copy number gain of the MYC transcription factor were identified in all 3 specimens.