The c.311T > C (p.L104P) pathogenic variant of the serine protease 1 (PRSS1) gene (encoding cationic trypsinogen) is frequently found in families with hereditary chronic pancreatitis (HCP) [4, 5], often presents as recurrent acute pancreatitis and serves as precursor to CP [1, 6, 7]. This evidence concerns the gene PRSS1 and chronic pancreatitis.