PRRT2 and epilepsy: Furthermore, genotype-phenotype relationships are not precise with pathogenic PRRT2 variants, and it is unclear why some patients present with a self-limited epilepsy course and others develop DEEs.29 For example, the child who developed IESS shared the same genotype c.649dupC (p.Arg217Profs*8) as several children in the cohort who were diagnosed with SeLIE alone.