PRRT2 and epilepsy: This finding is supported by our single case with a whole-gene PRRT2 deletion (case 11) who was diagnosed with medically refractory GGE.12 Homozygous/compound heterozygous PRRT2 variants also disrupt the PRRT2 protein more than heterozygous variants and have been reported to cause a more severe phenotype.17,22,25 However, the 3 children with homozygous PRRT2 variants in our cohort did not display a severe epilepsy/neurologic phenotype.22,25 However, overall, our small sample size limited our ability to make meaningful genotype-phenotype correlations.