More recently, there are single reports of pathogenic PRRT2 variants causing additional epilepsy phenotypes, such as developmental and epileptic encephalopathy with spike-wave activation in sleep (DEE/EE-SWAS) and epilepsy of infancy with migrating focal seizures.9-12 It is unclear why some patients with pathogenic PRRT2 variants present with a self-limited form of epilepsy while others develop a more severe epilepsy course. This evidence concerns the gene PRRT2 and Seizure.