APOE and dementia: However, in some studies, subgroup analyses showed the efficacy of multidomain intervention among groups with good adherence to the intervention or high risk of cognitive decline, such as those who had positive amyloid PET scan, carried the apolipoprotein E ε4 allele, and had a high CAIDE dementia risk score (Andrieu et al., 2017; Sakurai et al., 2024).