ACTA2: actin alpha cardiac muscle 2; Afib: atrial fibrillation; AI: aortic insufficiency; CT: computed tomography; CTA: computed tomography angiography; FBN1: fibrillin 1; FMH: family medical history; HLD: hyperlipidemia; LDS: Loeys-Dietz syndrome; MHY11: myosin heavy chain 11; MRI: magnetic resonance imaging; MYLK: myosin light chain kinase; RCA: right coronary artery; TEE: transesophageal echocardiogram; TGFBRI: transforming growth factor beta receptor type I; TGFB1: transforming growth factor beta 1; TTE: transthoracic echocardiogram. Here, ACTA2 is linked to aortic valve insufficiency.