Although tau-deposition consistent with CTE is a common autopsy finding among prior professional ASF players, current pre- and post-mortem tau deposition studies have not been definitively linked to proposed clinical attributes, such as depression, anxiety, suicidality, and cognitive dysfunction (Iverson et al., 2023; Mez et al., 2021; Stern et al., 2019). The gene discussed is MAPT; the disease is major depressive disorder.