Other evidence of the importance ofthe leptin/LepR axis in pathologies are the reports of higher expression levels of both leptin and its receptors in various types ofcancer, such as prostate and breast cancer; specifically in breast cancer these increases have been significantly related to distantmetastasis, other types of cancer where overexpression of leptin and leptin receptors has been observed is endometrial cancer andgastric cancer [5]. The gene discussed is LEP; the disease is breast cancer.