SPC25 mRNA expression is upregulated in HCC tissues, and its transcriptional level is significantly higher in Asian patients compared to Caucasians. SPC25 promotes liver cancer cell proliferation in vitro and tumor growth in vivo by accelerating the cell cycle. Several transcription factors, miRNAs, and immune cells potentially interacting with SPC25 have been identified. This evidence concerns the gene SPC25 and liver cancer.