SPC25 and breast cancer: SPC25 is upregulated in BC tissues and is associated with increased recurrence rates and decreased survival in patients. High SPC25 expression correlates with shorter distant metastasis-free survival, relapse-free survival, and OS. Single-cell analysis and functional assays indicate that SPC25 promotes BC cell proliferation by regulating the cell cycle and DNA damage repair, while its knockout inhibits proliferation. miRNAs, circRNAs, RNA-binding proteins, transcription factors, and immune factors may interact with SPC25 mRNA to further drive BC development and progression.