SPC25 transcription and protein expression are elevated in most cancers and predict survival in patients with ACC, CESC, KIRC, KIRP, LIHC, LUAD, MESO, STAD, THYM, and UCEC. SPC25 is also closely associated with TMB, MSI, immune-related pathways, immune cell infiltration, immune checkpoint genes, and other immune regulation-related genes. The gene discussed is SPC25; the disease is adrenal cortex carcinoma.