Genes involved in myelination and axon ensheathment tend to have higher expression in the Trem2−/− NBH group but decreased expression in Trem2−/− mice inoculated with prion disease (Mbp, Plp1, Mog, Mag, Mal, and Mobp) (Figure 6D, Supplementary Figure S2, Supplementary Table S1). The gene discussed is TREM2; the disease is prion disease.