TREM2 and prion disease: Wild-type (WT) mice and Trem2−/− mice infected with ME7 scrapie prions showed no significant difference in the onset (142 ± 2.57 dpi WT and 142 ± 2.57 dpi Trem2−/−) of the clinical signs of prion disease (including kyphosis, lethargy, unkempt hair, and ataxia) or duration to clinical end-stage (154 ± 2.56 dpi WT and 154 ± 1.98 dpi Trem2−/−) between genotypes (Figure 1A).