PBRM1 and major depressive disorder: SNORD 115 dysfunction, reported in 3 case reports [57], is hypothesized to contribute to catatonia across various neuropsychiatric disorders, including autism, schizophrenia, bipolar disorder, and major depressive disorder, as well as genetic and immune-related conditions through the regulation of five downstream genes: CRHR1, PBRM1, TAF1, DPM2, RALGPS1 and the alternative splicing of serotonin 2C receptor [57].