The increase in methylation level in lesions which progressed from LSIL to HSIL is suggested to be driven by the HPV E6 and E7 oncoproteins which upregulate the activity of the human DNA methyltransferases (DNMTs), specifically DNMT1a and DNMT3b thereby promoting tumor suppressor gene silencing by methylation of their promoter regions [30, 31]. This evidence concerns the gene DNMT3B and neoplasm.