The fibrogenic influence of CEMIP, previously identified in osteoarthritis chondrocytes45 and synovial membranes,44 as well as its induction of fibrosis in Crohn's disease46 and idiopathic pulmonary fibrosis,47 emphasises its central role in diseases characterised by abnormal ECM remodelling and fibrosis. Here, CEMIP is linked to osteoarthritis.