While the expression of TRPM2 and TRPV2 is increased in the colon of the 2,4,6‐trinitrobenzenesulphonic acid‐induced IBD rat model, oral administration of econazole (TRPM2 inhibitor)38 and TRPV2 inhibitor39 helps to reduce visceral hypersensitivity. This evidence concerns the gene TRPM2 and inflammatory bowel disease.