Research has shown that variations in chemoresistance and virulence of melanoma are attributed to the presence of CSCs in tumors, including CD133 (Cluster of differentiation 133) [13], ABCB5 (ATP-binding cassette sub-family B member 5) [14], ALDH (Aldehyde dehydrogenase) [15], CD20 [16], CD271 [17], and SOX10 (SRY-Box transcription factor) [18]. Here, PROM1 is linked to melanoma.