CDC42BPA and neoplasm: Additionally, activated Notch in human epidermal cells and SCC tumor cells inhibits the expression of ROCK2 and MRCKα (myotonic dystrophy kinase-related Cdc42-binding kinase), impairing cell migration and favoring the development of well-differentiated tumors by disrupting the expression of integrin α6β4 and Wnt7a [366].