CD274 and cancer: Eight distinct cell type features were identified, ranging from immune “cold” phenotypes of high cancer cell proportions and low immune cell proportions (e.g., feature with only cancer cells; cancer with few CD163 + cells; cancer with few CD68 + cells); to immune “hot” phenotypes with a majority of immune cells present (e.g., CD68-rich (CD68++), CD163-rich (CD163++), T lymphocyte-rich (CD3++), overall immune cell-rich (Immune rich)) and a group with high PDL1 expression on macrophages (PDL1-macrophage).