Specifically, various growth factors and molecular pathways, such as TGF-β1/Smad, PI3 K/AKT, adipsin, CXCL1/8, CK 18+19, and interleukin-6, potentially contribute to the tumor microenvironment and tumorigenesis in breast cancer cells [53–57]. This evidence concerns the gene TGFB1 and breast cancer.