Specifically, various growth factors and molecular pathways, such as TGF-β1/Smad, PI3 K/AKT, adipsin, CXCL1/8, CK 18+19, and interleukin-6, potentially contribute to the tumor microenvironment and tumorigenesis in breast cancer cells [53–57]. The gene discussed is AKT1; the disease is neoplasm.