A total of 66 women aged 18–40 were included in this retrospective cohort study, with 36 in the PCOS with elevated prolactin group (median 24.0 (22.0–27.5) years) and 30 in the prolactinoma group (median 28.0 (23.7–33.0) years). The gene discussed is PRL; the disease is polycystic ovary syndrome.