While earlier studies by Prelevic and Chapman focused on the effects of dopamine agonists on LH levels in PCOS, a more recent study by Hamad et al. examined 75 hyperprolactinemic women with PCOS, divided into three treatment groups: metformin alone (500 mg twice daily), CAB alone (0.5 mg once weekly), and a combination of both treatments for 90 days. The gene discussed is PLOD1; the disease is polycystic ovary syndrome.