Bourgeois et al. [34] linked EYA transcriptional coactivator and phosphatase 1 (EYA1) SNP (rs12678747, intronic variant) to aspirin-related peptic ulcers, and Xu et al. [35] found the Platelet endothelial aggregation receptor 1 (PEAR1) A allele rs12041331 (c.− 9- 3996G>A, intronic variant) is linked to aspirin bleeding risk. This evidence concerns the gene PEAR1 and peptic ulcer disease.