Cho et al. [36] associated IL-1β gene variants with aspirin-related peptic ulcers, and Forgerini et al. [37] linked not only CYP2C9*3 but also Vitamin K epoxide reductase complex subunit 1 (VKORC1) variants to NSAID-related upper GI bleeding. The gene discussed is VKORC1; the disease is peptic ulcer disease.