These top IBD-associated SNPs included NOD2 p.R702W (rs2066844), NOD2 p.G908R (rs2066845), NOD2 p.L1007fs (rs2066847), IL23R p.R381Q (rs11209026, protective), LRRK2 p.R1398H (rs7133914, protective), and LRRK2 p.N2081D (rs33995883). This evidence concerns the gene IL23R and inflammatory bowel disease.