We found that, in addition to a broad induction of ISGs (for example, DTX3L, OAS3, RTP4, IRF7, MX2, IFIT3, IFIH1), only IFNB1 and, more robustly, IFNL1-like and IFNL3-like were induced in virus-infected organoids at 1 and 3 days after infection compared to the uninfected controls (Fig. 6b and Supplementary Table 5). This evidence concerns the gene RTP4 and infection.