RUNX1 and neoplasm: Earlier, we identified the small-molecule inhibitor 7.44 (molecular weight 341 Da) (Fig. 1A), which was shown to (i) specifically interfere with NHR2, (ii) restore gene expression down-regulated by RUNX1/ETO, (iii) inhibit the proliferation, and (iv) reduce the RUNX1/ETO-related tumor growth in a mouse model19.